Silica Gel is one of the stationary phases used in flash column chromatography. The Silica Gel mesh size is very important for the successful completion of the chromatography process. Usually, Silica Gel with higher mesh size is preferred for this form of chromatography as it will absorb the components faster and thus improve the speed of the chromatography process. The larger mesh size works well while purifying organic compounds as it can separate the components more effectively. Silica Gel 230–400 Mesh size helps the flash chromatography process become more flexible and increases reproducibility as well.